Shark Cartilage Arthritis Knee Symptoms

Chemically, chondroitin sulfate is a glucosaminoglycan, with alternating n-acetylgalactosamine and glucuronic acid units in the chain. However, there are a great number of combinations, and it isn’t economically viable to try to separate these and there’s been no evidence that it is necessary.

Because the chondroitin chain can be made up of more than a hundred different sugars that can be sulfated to various degrees and in different positions, then it is easy to see how chondroitin sulfate isn’t an individual chemical entity. Nevertheless, it is seen as such, and there is no reason to separate the various possible combinations since its effect on osteoarthritis appears to remain constant and therefore not be dependent on any specific chemical composition.

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The substance can be extracted from shark cartilage, of which it is a large component, and likewise from the trachea and cartilage of cattle and fowl. It is also possible to manufacture the substance synthetically. It is a very important role in the structure of cartilage and is responsible for most of the resistance of cartilage to compression. Chondroitin together with glucosamine is widely used as a dietary supplement by those suffering from osteoarthritis.

There are two types of arthritis: osteoarthritis and rheumatoid arthritis. They’re completely different types of condition. Rheumatoid arthritis is caused by the immune system attacking the joints. In fact it’s a systemic condition that also affects the heart, the blood vessels, and other areas of the body, but it’s in the joints that the effects are most noticeable. It is an inflammatory condition, predominantly treated with anti-inflammatories, and chondroitin and glucosamine have no effect in its treatment.

Osteoarthritis, on the other hand, can have inflammatory components, particularly when the bone becomes eroded, but that isn’t result of the condition. It is caused by wear tear, and is frequently seen in athletes or those that have excess pressure consistently placed on their joints such as blacksmiths and other used to handling heavy weights. The cartilage becomes worn and thin. Eventually they lose their protection and shock absorbance properties that protect the clappers in the joint concerned.

Eventually the bones start to abrade, and the synovial fluid that lubricates the joint breaks down and loses its lubricant properties. This can cause inflammation and swelling. Eventually the condition becomes so painful that in extreme conditions the joint can seize up completely.

The use of chondroitin in osteoarthritis has been studies since the 1980s, most reporting good results in respect of alleviation of improved mobility, pain, and a decrease in the need for anti-inflammatories. The chondroitin can help to fix the cartilage and reduce pain, particularly with those that suffer moderate to severe pain levels. This is particularly true in the case in osteoarthritis of the knee or the hip.

The benefits it appears to include in addition to a decrease in pain levels include improved functionality, and making walking a bit easier. Chondroitin treatment also reduces stiffness in the joint, helps to obtain the swelling down and the findings appear to continue for about three months after stopping treatment.

Although there has been some debate on the oral bioavailability of such a large molecule as chondroitin sulfate, much of the evidence is that it can be absorbed orally and be bioavailable up to just over 20 percent of the dose. It therefore makes sense to assume a larger dose, and doses of 3, three grams, or 000 mg, aren’t unusual, and also do no harm. Tracer studies have shown that a large proportion of chondroitin ingested is in the cartilage and under the synovial fluid that lubricates the joints.

So how does chondroitin sulfate work to effect these improvements? There has been a great deal of work carried out to find this out. It appears that there are many factors involved.

Collagens are the main forms of connective tissue in your joints, that help to form cartilage, the tendons, and so on, and there’s a form of collagen that are also proteoglycans. In rheumatoid arthritis collagen and the connective tissues can be can be attacked and inflamed by the immune system, but in osteoarthritis, chondroitin sulfate can serve to strengthen and repair damaged cartilage and connective tissue by glycosylating those specific proteoglycans to form collagen.

Articular cartilage is the form of cartilage that covers the surface area of joints that allow movement, like the knee and hip joints. Chondrocytes are the cells from which cartilage is made. their death destroys articular cartilage and so causes osteoarthritis. There are substances that can and do destroy these cells, including nitric oxide and proteolytic enzymes. Chondroitin sulfate inhibits the establishment of these substances in the body, and not only helps to prevent arthritis occurring, but also help to repair the harm that has been carried out by these substances on the cartilage.

These are three of the most important ways in which chondroitin sulfate is thought to work so as to reduce the incidence of osteoarthritis and also to repair the damage that it causes. Chondroitin sulfate is thought to be a natural component of joint tissue. This is reason, it is believed to work when introduced to diseased joints. However, recent studies have indicated another two ways in which the supplement could work in your joints.

However, these involve concepts such as subchondral bone, the bone immediately under the cartilage that protects it and also transcription factors, both of which are outside the scope of this article. However, it is encouraging to note that new evidence and justification of how this previously maligned supplement operate to relieve the symptoms of osteoarthritis.

Chondroitin sulfate can promote the state of health of connective tissue such as cartilage, tendons and ligaments, and the manner in which it works is now being scientifically established. It can be used with confidence by anybody suffering from this form of arthritis.